Endometrial Biopsy during Infertility Investigation

In the course of infertility assessment, an endometrial biopsy is one diagnostic tool used to investigate hormonal imbalances that can lead to irregular cycles, frequent miscarriages, or even irregular uterine bleeding. It is indicated when diseases of the endometrium are suspected to be the cause of the infertility and also to find out how ready the endometrium is to accept the implantation of an embryo. The test analyzes whether the lining of a woman’s uterus can support a pregnancy. During an endometrial biopsy a soft, straw-like device (pipelle) or any other pliable instrument is used to suction a small sample of lining from the uterus. The endometrial lining is then analyzed in a lab for abnormal cells.

Problems with the endometrium are called “luteal phase defect", which is a hormonal disorder. An endometrial biopsy checks to see if the endometrium can support implantation and growth of a fertilized egg. The entire procedure takes less than 10 minutes and is far less invasive than a hysteroscopic procedure. The biopsy is usually done about three days before the start of the period. Prior to the biopsy, if a pregnancy is suspected, a pregnancy test must be done to rule out this possibility.

Endometrial biopsy and Infertility
In women with infertility issues, it is very important to know what causes this infertility. The outcome of an endometrial biopsy may determine whether there exists a progesterone deficiency, an estrogen deficiency, or a luteinizing hormone (LH) deficiency. Depending on the hormonal imbalance, a hormone supplement or a prescription drug may be recommended. The test can also be used to check for infection and if this is discovered, a D&C may be needed and/or treatment with antibiotics.

Thus an endometrial biopsy is sometimes necessary to determine the cause of infertility and in some cases the infertility can be reversed. This is a useful tool to detect hormone imbalance that may be the cause of infertility and the doctor will usually prescribe progesterone to relieve it. Thus by performing the simple endometrial biopsy for infertility, a couple may have well taken the first step towards having a child.

East Bay fertility clinic specializes in the comprehensive evaluation and treatment of infertility. Their experienced medical staff is headed by Dr. Ellen U. Snowden, Medical Director and physician. Dr Snowden is Board Certified in Obstetric, Gynecology, and Reproductive Endocrinology with advanced Fellowship training in the treatment of infertility, recurrent miscarriages and hormonal disorders in women. A former infertility patient herself, Dr. Snowden brings to her patients a rare and valuable firsthand empathy for the personal pain and emotional stress of dealing with infertility. Call 925.828.9235 for a free initial consultation.